Transcription to follow: There are patients able to overcome their nausea and vomiting from their chemotherapy and perhaps even be cured of these malignancies by using cannabis. But what really started me in my research was in my work with HIV AIDS patients. Again seeing them being eaten alive if you will by the AIDS wasting syndrome, which was a common sort of end of life phenomenon that we had before we discovered effective anti retroviral drugs and about the time Delta-9 THC was approved, thats the drug durnabinol or marinol, for treatment for this wasting syndrome in HIV patients. We began to hear from these patients that they actually preferred smoking the cannabis because of their ability to titrate the effect better than swallowing a pill. We know now that cannabis taken by mouth either as baked product or the medication Delta-9 THC has much different absorbs ion and kinetics. It takes a much longer time to reach a much lower peak and then it stays in the system for quite a while. Whereas when it is inhaled, either smoked or vaporized, the peak plasma concentration is actually reached in about 2 minutes and then falls over the next 30 minutes. So the effect happens more rapidly and perhaps dissipates more rapidly. When taken by mouth, the Delta-9 THC, then main psychoactive component is metabolized in the liver to a 11 hydroxy form that is also psychoactive. So when eaten as either a baked product or as the pill the Delta-9 THC creates this psychoactive metabolite …

Be Sociable, Share!

•